This manual is for busy clinicians and managers. It can help to improve the quality of care by explaining how to apply guidelines in a wide variety of clinical settings. Case studies written by the protagonists themselves describe the experiences of using guidelines in treating a wide range of conditions in primary and secondary care. The final sections collate the lessons learnt from these examples, and propose practical solutions that can be applied in everyday clinical care by doctors, nurses, professionals allied to medicine, and healthcare managers.