This volume contains the proceedings of the 2nd International Workshop on Contemporary Problems in Mathematical Physics. The following topics are discussed: developments in operator theory, coherent states and wavelet analysis; geometric and topological methods in theoretical physics and quantum field theory; and applications of these methods of mathematical physics to problems in atomic and molecular physics as well as the world of the elementary particles and their fundamental interactions. The volume should be of interest to anyone working in a field using the mathematical methods associated with any of these topics.