In the first book to focus on relations between Indians and emigrants on the overland trails, Michael L. Tate shows that such encounters were far more often characterized by cooperation than by conflict. Having combed hundreds of unpublished sources and Indian oral traditions, Tate finds Indians and Anglo-Americans continuously trading goods and news with each other, and Indians providing various forms of assistance to overlanders.

Despite thousands of mutually beneficial exchanges between whites and Indians between 1840 and 1870, the image of Plains Indians as the overland pioneers' worst enemies prevailed in American popular culture. In explaining the persistence of that stereotype, Tate seeks to dispel one of the West's oldest cultural misunderstandings.