This book constitutes the refereed proceedings of the 16th International Conference on Information Processing in Medical Imaging, IPMI'99, held in Visegrad, Hungary in June/July 1999. The 24 revised full papers and the 28 posters presented have been carefully reviewed and selected from a total of 82 submissions. The volume addresses the full range of current topics in the area in particular new imaging techniques, 3D ultrasound and PET, segmentation, image analysis of the brain cortex, registration, feature, detection and modelling, cardiovascular image analysis, shape modelling and analysis, segmentation and detection, measurement and quantitative analysis, and analysis of image sequences and functional imaging.