This book focuses on a prototype of creative causal processes termed BIOS and how the concept can be applied to the physical world, in medicine and in social science. This book presents methods for identifying creative features in empirical data; studies showing biotic patterns in physical, biological, and economic processes; mathematical models of bipolar (positive and negative) feedback that generate biotic patterns. These studies support the hypothesis that natural processes are creative (not determined) and causal (not random) and that bipolar feedback plays a major role in their evolution. Simple processes precede, coexist, constitute and surround the complex systems they generate (priority of the simple). In turn, complex processes feedback and transform simpler ones (supremacy of the complex).