This book constitutes the refereed proceedings of the 5th International Conference on Tools and Algorithms for the Construction and Analysis of Systems, TACAS'99, held in Amsterdam, The Netherlands in March 1999 as part of ETAPS'99. The 28 revised full papers presented were carefully reviewed and selected from a total of 82 submissions. Also included are one invited paper, a position statement, and one ETAPS tool demonstration. The papers are organized in topical sections on real-time systems, case studies, compositionality and abstraction, symbolic analysis, process algebras, frameworks for system construction and analysis, and tool descriptions.