libcats.org
Главная

Drug Discovery and Evaluation

Обложка книги Drug Discovery and Evaluation

Drug Discovery and Evaluation

, ,
Safety aspects have become an outstanding issue in the process of drug discovery and development. Until 15 years ago, drug discovery and evaluation was a sequential process starting with the selection of the most active compound from a series of newly synthesized compounds by means of special pharmacological assays. Safety aspects were addressed by pharmacological testing of the selected compound in high doses in tests directed at indications other than the intended indication of the new compound. These tests were followed by pharmacokinetic studies, which were mainly aimed at confirming of a suitable half-life time and at oral activity. Safety aspects relied mostly on toxicity studies, which however gave information on changes of organ structure rather than on organ function. Toxicological and pharmacokinetic studies were adapted to the progress of studies in clinical pharmacology and clinical trails.
Популярные книги за неделю:

Ключ к сверхсознанию

Автор:
Категория: Путь к себе
Размер книги: 309 Kb

Древо жизни

Автор:
Категория: Путь к себе
Размер книги: 1.70 Mb

Contemporary Theatre, Film and Television, Volume 97

Автор:
Размер книги: 3.18 Mb

Шликерное литье

Автор:
Категория: science, science, technical
Размер книги: 5.98 Mb
Только что пользователи скачали эти книги:

Linda Howard - 36 Book Compilation

Автор:
Размер книги: 5.86 Mb

THE INSANITY OF JUDAISM by Newton Joseph

Автор:
Размер книги: 2 Kb

Alexandre Grothendieck's EGA V

Автор: , Автор:
Размер книги: 1021 Kb

Yeast Protocols (Methods in Molecular Biology) (Methods in Molecular Biology)

Автор:
Категория: Biochemistry
Размер книги: 6.60 Mb

Longman Photo Dictionary of American English

Автор:
Категория: НАУКА и УЧЕБА
Размер книги: 21.34 Mb

The Silver Spoon

Автор:
Категория: fiction
Размер книги: 507 Kb