Methodologies used to analyse the genomes of prokaryotes and eukaryotes are advancing very rapidly as it has been realized that there is a resolution gap between what can be viewed under the microscope and what molecular techniques can resolve. This book presents current, successful strategies for construction of physical maps to identify and analyse the arrangement and function of genes. These techniques, which are applicable to a range of organisms, are being used to move from linked markers to candidate genes in several human monogenic disorders. They are presented in a way that should enable any research or diagnostic laboratory to apply them to their particular systems. Also included are descriptions of new probes and approaches for the localization of human disorders whose analysis has so far eluded the molecular geneticist.

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