This issue, our first two topic issue, covers the essential information that general diagnostic radiologists need to know in the areas of chest imaging and neuroimaging. In the thoracic section, imaging of the solitary pulmonary nodule, lung cancer and other malignancies, vascular disease, and infection are reviewed. In the neuroimaging section, imaging of multiple sclerosis, spine trauma, lymph node evaluation, stroke, vascular injury, and pediatric emergencies.