This multi-authored book provides an updated description of climate variability in the Mediterranean basin, focusing on decadal and centennial time scales and on the results available on the impact of future emission scenarios at regional scale. The authors describs both local physical processes responsible for these variability - such as changes in the surface properties and land use- and globalprocesses - such as changes in the large scale atmospheric circulation associated to global warming, NAO, tropical monsoon and ENSO. Regional climate change issues are also addressed.