Now completely revised and updated, this ground-breaking text focuses on the borderland between histology and pathology. The text describes human histology and its variations, with emphasis on avoiding overdiagnosis or misdiagnosis of normal variants. Presented by leading international specialists in pathology, histopathology, anatomical pathology, surgical pathology, and neuropathology, the text is innovative, well organized and generously illustrated. Coverage includes the structure, composition, and function of tissues from a pathologic perspective; a systematic review of each major organ system, as well as structures of special significance; and histologic subtleties, such as unusual variations in staining reactions, little-known fixation artifacts, and frequently missed gross observations. This edition is reorganized to better reflect an organ-system approach to histology. Immunohistochemical findings in normal tissues have been added, based on the latest antibody panels.