MGSA/GRO is a CXC chcmokinc which shares Structural features and many biological activities with IL-8. It is widely expressed in melanocytes, melanoma, keratinocytes. monocytes and macrophages, mammary epithelial cells, and endothelial cells. Previously. MGSA/GRO was found to be important for recruitment and activation of neutrophils, lymphocytes, and monocytes in host defense. Now, it has become apparent that MGSA/GRO plays an important role in wound healing, growth regulation, angio-genesis, tumorigenesis. and apoptosis. The expression of the MGSA/GRO ligands and receptors has been detected in a number of inflammatory disorders and in viral infections.