There were over 190 authors involved in writing the protocols, ...each protocol is presented in outline format an follows a common numbering scheme, making it easy to find relevant sections....Many of the protocols include tables of data or figures, including drawings or photographs of gels...One of the most useful sections in each protocol lists notes, which elucidate possible pitfalls, provide troubleshooting tips, or give alternate methods or explanations for steps. This very practical information makes successful duplication of the procedure much more likely than when attempting to follow the often less detailed or less flexible descriptions given in journal articles....this handbook would be extremely useful as a reference in most university libraries.