Assembles detailed protocols designed exclusively for clinical applications, often described by the scientists who developed or refined them in their own laboratories. They furnish new and more powerful assays for many routine serum and blood tests now regularly performed in clinical laboratories, including serum and urine proteins; hemoglobin separation; and detecting CSF proteins, lipoproteins, myoglobin, cryoglobulins, and cathepsin D. The protocols for DNA analysis include double-stranded DNA analysis, the prenatal diagnosis of Down's syndrome, Rh D/d genotyping, identifying the mutated p53 oncogene, and detecting microsatellite instability in cancer.

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