CCR8 is a CC chcmokine receptor mostly homologous to CCR4 (44%). CCR8 mRNA has been detected in lymphoid tissues such as thymus, spleen, and lymph nodes. In particular. CCR8 message is expressed by CD4 I and CD4 I CD8 I thymocytes, and by CD4 I and CD8 I peripheral blood T lymphocytes. This pattern of expression suggests a role for this receptor and its ligands in the differentiation, and activation/migration of T lymphocytes. CCR8 may also be considered as a molecule associated with the TH2 program, being abundantly expressed by NK1.1 I CD4I cells and by TH2 cells that migrate in response to CCR8 ligands. thus suggesting an important role of 1-309 CCR8 in allergic diseases.The main agonists of CCR8 are represented by the eukaryotic CC chemokine 1-309 and by vMIP-I, an HHV-8-encoded protein, that induce both calcium mobilization and chemotaxis in cellular transfectanls overexpressing CCR8.A role for this receptor in modulating HIV infection is indicated by the demonstration that several HIV and SIV isolates utilize CCR8 as a coreceptor for viral entry/fusion and by the inhibition of CCR8-medialed HIV infection shown by 1-309.

Скачать книгу бесплатно (pdf, 82 Kb)

---

Читать «CCR8»