The application of computational methods to DNA and protein science is the newest and most exciting new development in biology. "Bioinformatics: Sequence and Genome Analysis" is a comprehensive functional and theoretical introduction to this new discipline. Sequence alignment, structure prediction, phylogenetic and gene prediction, database searching, and genome analysis are amply explained and illustrated. Descriptions, instructions, and web references are provided for a broad range of publicly available software. Links to online resources, problems for classroom use, and additional material not included in the text are available on the book's own website, that will be updated as the field moves on. Based on the author's extensive teaching experience at the University of Arizona, this is a uniquely educational book, ideal for investigators, graduate students, and biology undergraduates studying this new, fast-changing discipline, and also for computer programmers and information specialists working in molecular biology and pharmaceutical laboratories.