IP-10 is a CXC chemokine that is induced from most cells in response to both type I and type II interferon stimulation and LPS. IP-10 is chemotactic for activated T cells and NK cells by binding to and activating CXCR3. IP-10 also has antiangiogenic and antitumor activity in vivo. IP-10 expression has been seen in many TH 1-type human inflammatory diseases and plays an important role in recruiting activated effector T cells into sites of tissue inflammation.