Work in the field of neuroprosthetics requires multidisciplinary teams, but these collaborators must meet on common ground to develop an understanding of the capabilities and limitations of each part of a bioengineering project. This handbook combines the basic concepts, applications, and knowledge of materials science, neural systems, electrical systems, system interfacing, and signal processing. It provides a comprehensive resource for the techniques, methodologies, and options needed to properly design and undertake experiments within the field of neuroprosthetics. It will be welcomed for fostering more effective, profitable, and productive collaborations.