Using the National Research Council's 1992 Spacecraft Maximum Allowable Concentrations guidelines as a general model, this study articulates the principles of developing spacecraft water exposure guidelines. The authors considered the sources of spacecraft water contaminants, the methods of ranking contaminants for risk assessment purposes, the predicted toxicity for humans in space, risk assessment methods, the altered physiological changes and stresses of microgravity, and the exposure guidelines developed by other organizations

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